منابع مشابه
MiR-146b-5p overexpression attenuates stemness and radioresistance of glioma stem cells by targeting HuR/lincRNA-p21/β-catenin pathway
A stem-like subpopulation existed in GBM cells, called glioma stem cells (GSCs), might contribute to cancer invasion, angiogenesis, immune evasion, and therapeutic resistance, providing a rationale to eliminate GSCs population and their supporting niche for successful GBM treatment. LincRNA-p21, a novel regulator of cell proliferation, apoptosis and DNA damage response, is found to be downregul...
متن کاملLincRNA-p21 suppresses target mRNA translation.
Mammalian long intergenic noncoding RNAs (lincRNAs) are best known for modulating transcription. Here we report a posttranscriptional function for lincRNA-p21 as a modulator of translation. Association of the RNA-binding protein HuR with lincRNA-p21 favored the recruitment of let-7/Ago2 to lincRNA-p21, leading to lower lincRNA-p21 stability. Under reduced HuR levels, lincRNA-p21 accumulated in ...
متن کاملKul Hur
By using the notion of fuzzy functions introduced by Dib and Youssef, we obtain fuzzy analogues of some results concerning ordinary functions. In particular, we give the definition different from one of invertible fuzzy function introduced by Dib and Youssef. And we show that the two definitions are equivalent. Furthermore, we introduce the concepts of fuzzy increasing functions and fuzzy isomo...
متن کاملHuR function in disease.
The cytoplasmic events that control mammalian gene expression, primarily mRNA stability and translation, potently influence the cellular response to internal and external signals. The ubiquitous RNA-binding protein (RBP) HuR is one of the best-studied regulators of cytoplasmic mRNA fate. Through its post-transcriptional influence on specific target mRNAs, HuR can alter the cellular response to ...
متن کاملNeurodevelopmental LincRNA Microsyteny Conservation and Mammalian Brain Size Evolution
The mammalian neocortex has undergone repeated selection for increases and decreases in size and complexity, often over relatively short evolutionary time. But because probing developmental mechanisms across many species is experimentally unfeasible, it is unknown whether convergent morphologies in distantly related species are regulated by conserved developmental programs. In this work, we hav...
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ژورنال
عنوان ژورنال: Molecular Cell
سال: 2013
ISSN: 1097-2765
DOI: 10.1016/j.molcel.2013.09.024